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Forms available from special-order manufacturers include: Generally there are few compatibility problems with common two and three drug combinations containing:. Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding. Sign Up Log In Cancel. Valoid may counteract the haemodynamic benefits of opioid analgesics. Also used as anticonvulsant. Inability to take medication orally.

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Syringe Drivers In this article Setting up the syringe driver Drugs used in the syringe driver Drug compatibility Problems with syringe drivers.

Active ingredient cyclizine lactate. It possesses anticholinergic and antiemetic properties. General side-effects Rare or very rare Angle closure glaucoma ; depression.

Hyoscine hydrobromide for excess respiratory secretions 1. Norcyclizine has little antihistaminic H 1 activity compared to cyclizine and has a plasma elimination half life of approximately 20 hours. By intravenous injection, or by intramuscular injection. Date of revision of the text.

Cyclizine Lactate 50 mg/ml Injection

Hypersensitivity to the active substance or to any of the excipients listed in section 6. It syyringe most frequently used in palliative care particularly cancer carebypassing problems such as: General disorders and administration site conditions Not known Asthenia Injection site reactions including vein tracking, erythema, pain, thrombophlebitis and blisters.

Some of the patients mentioned in these case reports had an underlying neuromuscular disorder. Drug and Indication Dose Other Comments Diamorphine for pain If the syriinge is not receiving oral morphine, mg per 24 hours, or total oral dose in mg in last 24 hours divided by 3.


For administration by mouthtablets may be crushed. Sign Up Log In Cancel. Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding. Cyclizine is a histamine H 1 receptor cycliziine of the piperazine class which is characterised by a low incidence of drowsiness.

For vomiting secondary to opiates, uraemia, hypercalcaemia and intestinal obstruction. In the management of acute overdosage with Valoid, gastric lavage and supportive measures for respiration and circulation should be performed if necessary.

CYCLIZINE | Drug | BNF content published by NICE

The relevance of these studies to the human situation is not known. The concomitant misuse of Valoid with large amounts of alcohol is particularly dangerous, since the antiemetic effect of cyclizine may increase the toxicity of alcohol see also Section 4. Forms available from special-order manufacturers include: There have been reports of abuse of cyclizine, either oral or intravenous, for its euphoric or hallucinatory effects.

Qualitative and quantitative composition 3. You can opt dyringe at any time or find out more by reading our cookie policy. Eye disorders Not known Blurred vision, oculogyric crisis Dosqge system disorders Not known Dryness of the mouth, nose and throat, constipation, increased gastric reflux, nausea, vomiting, diarrhoea, stomach pain, dosge of appetite. Last updated on eMC: Central nervous system effects include drowsiness, dizziness, incoordination, ataxia, weakness, hyperexcitability, disorientation, impaired judgement, hallucinations, cyclizihe, extrapyramidal motor disturbances, convulsions, hyperpyrexia and respiratory depression.


Cyclizine was not mutagenic in a full Ames test, including use of S9-microsomes but can nitrosate in vitro to form mutagenic products. Frequency not known Abdominal pain ; agranulocytosis ; angioedema ; anxiety ; apnoea ; appetite decreased ; arrhythmias ; asthenia ; bronchospasm ; constipation ; diarrhoea ; disorientation ; dizziness ; drowsiness ; dry mouth ; dry throat ; euphoric mood ; haemolytic anaemia ; hallucinations ; headache ; hepatic disorders ; hypertension ; hypotension ; increased gastric reflux ; insomnia ; leucopenia ; movement disorders ; muscle complaints ; nasal dryness ; nausea ; oculogyric crisis ; palpitations ; paraesthesia ; photosensitivity reaction ; seizure ; skin reactions ; on disorder ; thrombocytopenia ; tinnitus ; tremor ; urinary retention ; vision blurred ; vomiting.

The plasma elimination rosage was approximately 20 hours.

Syringe Drivers

By continuous intravenous infusion, or by subcutaneous infusion. Neonate due to significant antimuscarinic activity in neonates.

Valoid may counteract the haemodynamic benefits of opioid analgesics. It does not im more effective analgesia than the oral route unless the patient cannot use oral medication, or has serious compliance problems.